Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

A novel series of 5,7-dibromoisatin analogs were synthesized and evaluated for their cytotoxicities against four human cancer cell lines including colon HT29, breast MCF-7, lung A549 and melanoma UACC903. Analogs 6, 11 and 13 displayed good in vitro anticancer activity on the HT29 human colon cancer...

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Main Authors: Krishnegowda, Gowdahalli, Gowda, A. S. Prakasha, Tagaram, Hephzibah Rani S., Staveley-O’ Carroll, Kevin F, Irby, Rosalyn B., Sharma, Arun K., Amin, Shantu
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235409/
https://ncbi.nlm.nih.gov/pubmed/21920762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.044
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