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The C-Terminal αI Domain Linker as a Critical Structural Element in the Conformational Activation of αI Integrins

The activation of α/β heterodimeric integrins is the result of highly coordinated rearrangements within both subunits. The molecular interactions between the two subunits, however, remain to be characterized. In this study, we use the integrin α(L)β(2) to investigate the functional role of the C-lin...

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Auteurs principaux: Weitz-Schmidt, Gabriele, Schürpf, Thomas, Springer, Timothy A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234956/
https://ncbi.nlm.nih.gov/pubmed/21965670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282830
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