Progesterone Receptor Inhibits Proliferation of Human Breast Cancer Cells via Induction of MAPK Phosphatase 1 (MKP-1/DUSP1)

The roles of progesterone (P(4)) and of progesterone receptor (PR) in development and pathogenesis of breast cancer remain unclear. In this study, we observed that treatment of T47D breast cancer cells with progestin antagonized effects of fetal bovine serum (FBS) to stimulate cell proliferation, wh...

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Bibliographic Details
Main Authors: Chen, Chien-Cheng, Hardy, Daniel B., Mendelson, Carole R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234857/
https://ncbi.nlm.nih.gov/pubmed/22020934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295865
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