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Helix 8 Plays a Crucial Role in Bradykinin B(2) Receptor Trafficking and Signaling

Upon activation the human bradykinin B(2) receptor (B(2)R) acts as guanine nucleotide exchange factor for the G proteins G(q/11) and G(i). Thereafter, it gets phosphorylated by G protein-coupled receptor kinases (GRKs) and recruits β-arrestins, which block further G protein activation and promote B(...

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Hlavní autoři: Feierler, Jens, Wirth, Markus, Welte, Benjamin, Schüssler, Steffen, Jochum, Marianne, Faussner, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234833/
https://ncbi.nlm.nih.gov/pubmed/22016392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.256909
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