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Helix 8 Plays a Crucial Role in Bradykinin B(2) Receptor Trafficking and Signaling
Upon activation the human bradykinin B(2) receptor (B(2)R) acts as guanine nucleotide exchange factor for the G proteins G(q/11) and G(i). Thereafter, it gets phosphorylated by G protein-coupled receptor kinases (GRKs) and recruits β-arrestins, which block further G protein activation and promote B(...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234833/ https://ncbi.nlm.nih.gov/pubmed/22016392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.256909 |
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