The Chimeric Approach Reveals That Differences in the TRPV1 Pore Domain Determine Species-specific Sensitivity to Block of Heat Activation

The capsaicin-, heat-, and proton-activated ion channel TRPV1, a member of the transient receptor potential cation channel family is a polymodal nociceptor. For almost a decade, TRPV1 has been explored by the pharmaceutical industry as a potential target for example for pain conditions. Antagonists...

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Main Authors: Papakosta, Marianthi, Dalle, Carine, Haythornthwaite, Alison, Cao, Lishuang, Stevens, Edward B., Burgess, Gillian, Russell, Rachel, Cox, Peter J., Phillips, Stephen C., Grimm, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234789/
https://ncbi.nlm.nih.gov/pubmed/21911503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.273581
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