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ST6Gal-I Regulates Macrophage Apoptosis via α2-6 Sialylation of the TNFR1 Death Receptor

Macrophages play a central role in innate immunity, however mechanisms regulating macrophage survival are not fully understood. Herein we describe a novel apoptotic pathway involving α2-6 sialylation of the TNFR1 death receptor by the ST6Gal-I sialyltransferase. Variant glycosylation of TNFR1 has no...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Zhongyu, Swindall, Amanda F., Kesterson, Robert A., Schoeb, Trenton R., Bullard, Daniel C., Bellis, Susan L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234788/
https://ncbi.nlm.nih.gov/pubmed/21930713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276063
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