Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin α(IIb)β(3) Outside-in Signaling

Rap1b is activated by platelet agonists and plays a critical role in integrin α(IIb)β(3) inside-out signaling and platelet aggregation. Here we show that agonist-induced Rap1b activation plays an important role in stimulating secretion of platelet granules. We also show that α(IIb)β(3) outside-in si...

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Detalhes bibliográficos
Main Authors: Zhang, Guoying, Xiang, Binggang, Ye, Shaojing, Chrzanowska-Wodnicka, Magdalena, Morris, Andrew J., Gartner, T. Kent, Whiteheart, Sidney W., White, Gilbert C., Smyth, Susan S., Li, Zhenyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234770/
https://ncbi.nlm.nih.gov/pubmed/21940635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.239608
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