Disruption of the Interface between the Pleckstrin Homology (PH) and Kinase Domains of Akt Protein Is Sufficient for Hydrophobic Motif Site Phosphorylation in the Absence of mTORC2

The pro-survival kinase Akt requires phosphorylation at two conserved residues, the activation loop site (Thr-308) and the hydrophobic motif site (Ser-473), for maximal activation. Previous reports indicate that mTORC2 is necessary for phosphorylation of the hydrophobic motif and that this site is n...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Warfel, Noel A., Niederst, Matt, Newton, Alexandra C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234737/
https://ncbi.nlm.nih.gov/pubmed/21908613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.278747
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