MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells

We previously demonstrated that MG-2477 (3-cyclopropylmethyl-7-phenyl-3H-pyrrolo[3,2-f]quinolin-9(6H)-one) inhibits the growth of several cancer cell lines in vitro. Here we show that MG-2477 inhibited tubulin polymerization and caused cells to arrest in metaphase. The detailed mechanism of action o...

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Détails bibliographiques
Auteurs principaux: Viola, Giampietro, Bortolozzi, Roberta, Hamel, Ernest, Moro, Stefano, Brun, Paola, Castagliuolo, Ignazio, Ferlin, Maria Grazia, Basso, Giuseppe
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234688/
https://ncbi.nlm.nih.gov/pubmed/21964343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.09.017
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