Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neuronal degeneration and whether defects in different repair systems affect the brain differently is largely unknown. Here, we performed a systematic detailed analysis of neurodegenerative changes in mouse...

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Detalhes bibliográficos
Main Authors: Jaarsma, Dick, van der Pluijm, Ingrid, de Waard, Monique C., Haasdijk, Elize D., Brandt, Renata, Vermeij, Marcel, Rijksen, Yvonne, Maas, Alex, van Steeg, Harry, Hoeijmakers, Jan H. J., van der Horst, Gijsbertus T. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234220/
https://ncbi.nlm.nih.gov/pubmed/22174697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002405
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