Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5.

Selective inhibition of regulatory immediate early (IE) genes of herpes simplex virus type 1 (HSV-1) should inhibit virus growth. Treatment of HSV-1-infected cells with the oligo(nucleoside methylphosphonate) d(TpCCTCCTG) (deoxynucleoside methylphosphonate residues in italic), which is complementary...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Smith, C C, Aurelian, L, Reddy, M P, Miller, P S, Ts'o, P O
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1986
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323391/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3010316/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.9.2787
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