Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading

To establish a causal role for locally produced IGF-I in the mechanical strain response in the bone, we have generated mice with conditional disruption of the insulin-like growth factor (IGF) I gene in type 1α(2) collagen-expressing cells using the Cre-loxP approach. At 10 wk of age, loads adjusted...

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Hauptverfasser: Kesavan, Chandrasekhar, Wergedal, Jon E., Lau, K.-H. William, Mohan, Subburaman
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233773/
https://ncbi.nlm.nih.gov/pubmed/21878662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00440.2011
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