Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis

The evolution of colorectal cancer suggests the involvement of many genes. We performed insertional mutagenesis with the Sleeping Beauty (SB) transposon system in mice carrying germline or somatic Apc mutation. Analysis of common insertion sites (CISs) isolated from 446 tumors revealed many hundreds...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: March, H. Nikki, Rust, Alistair G., Wright, Nicholas A., Hoeve, Jelle ten, de Ridder, Jeroen, Eldridge, Matthew, van der Weyden, Louise, Berns, Anton, Gadiot, Jules, Uren, Anthony, Kemp, Richard, Arends, Mark J., Wessels, Lodewyk F. A., Winton, Douglas J., Adams, David J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233530/
https://ncbi.nlm.nih.gov/pubmed/22057237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.990
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki