Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function

In this study, we report the functional characterization of a new ent-kaurene diterpenoid termed pharicin A, which was originally isolated from Isodon, a perennial shrub frequently used in Chinese folk medicine for tumor treatment. Pharicin A induces mitotic arrest in leukemia and solid tumor-derive...

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Main Authors: Xu, Han-Zhang, Huang, Ying, Wu, Ying-Li, Zhao, Yong, Xiao, Wei-Lie, Lin, Qi-Shan, Sun, Han-Dong, Dai, Wei, Chen, Guo-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233523/
https://ncbi.nlm.nih.gov/pubmed/20603598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.14.12406
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