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Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing

BubR1 is an important component of the spindle assembly checkpoint, and deregulated BubR1 functions frequently result in chromosomal instability and malignant transformation. We recently demonstrated that BubR1 was modified by sumoylation, and that lysine 250 (K250) functions as the crucial site for...

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Hlavní autoři: Yang, Feikun, Huang, Ying, Dai, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318109/
https://ncbi.nlm.nih.gov/pubmed/22374677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.4.19307
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