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Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing
BubR1 is an important component of the spindle assembly checkpoint, and deregulated BubR1 functions frequently result in chromosomal instability and malignant transformation. We recently demonstrated that BubR1 was modified by sumoylation, and that lysine 250 (K250) functions as the crucial site for...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318109/ https://ncbi.nlm.nih.gov/pubmed/22374677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.4.19307 |
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