Pancreatic expression of human insulin gene in transgenic mice.

We have investigated the possibility of obtaining integration and expression of a native human gene in transgenic mice. An 11-kilobase (kb) human chromosomal DNA fragment including the insulin gene (1430 base pairs) was microinjected into fertilized mouse eggs. This fragment was present in the genom...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bucchini, D, Ripoche, M A, Stinnakre, M G, Desbois, P, Lorès, P, Monthioux, E, Absil, J, Lepesant, J A, Pictet, R, Jami, J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323328/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3517871/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.8.2511
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