cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.

Membrane-permeant cAMP derivatives (dibutyryl- and 8-bromo-cAMP) increase gap-junctional conductance within minutes when applied to voltage-clamped pairs of rat hepatocytes. Glucagon also increases junctional conductances, but the response has a more rapid onset and is more rapidly reversible. The g...

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Bibliografiske detaljer
Main Authors: Saez, J C, Spray, D C, Nairn, A C, Hertzberg, E, Greengard, P, Bennett, M V
Format: Artigo
Sprog:Inglês
Udgivet: 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC323320/
https://ncbi.nlm.nih.gov/pubmed/3010311
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