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Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences

Assembly of the heterotrimeric influenza virus polymerase complex from the individual subunits PB1, PA, and PB2 is a prerequisite for viral replication. The conserved protein-protein interaction sites have been suggested as potential drug targets. To characterize the PB1-PB2 interface, we fused the...

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Main Authors: Reuther, Peter, Mänz, Benjamin, Brunotte, Linda, Schwemmle, Martin, Wunderlich, Kerstin
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233147/
https://ncbi.nlm.nih.gov/pubmed/21957294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00868-11
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