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In Vitro Generation of High-Titer Prions
Prions are composed mainly, if not entirely, of PrP(Sc), an infectious misfolded isoform of PrP(C), the normal isoform of the prion protein. Here we show that protein misfolding cyclic amplification (PMCA)-generated hypertransmissible mink encephalopathy (HY TME) PrP(Sc) is highly infectious and has...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233131/ https://ncbi.nlm.nih.gov/pubmed/21957291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06134-11 |
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