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Selection with a Peptide Fusion Inhibitor Corresponding to the First Heptad Repeat of HIV-1 gp41 Identifies Two Genetic Pathways Conferring Cross-Resistance to Peptide Fusion Inhibitors Corresponding to the First and Second Heptad Repeats (HR1 and HR2) of gp41

We generated four HIV-1 cultures that are resistant to a peptide fusion inhibitor corresponding to the first heptad repeat of gp41 in order to study mechanisms of resistance and gain insights into envelope glycoprotein-mediated membrane fusion. Two genetic pathways emerged that were defined by acqui...

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Библиографические подробности
Главные авторы: Wang, Wei, De Feo, Christopher J., Zhuang, Min, Vassell, Russell, Weiss, Carol D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233121/
https://ncbi.nlm.nih.gov/pubmed/21994458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05391-11
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