Exogenous Insulin Enhances Glucose-Stimulated Insulin Response in Healthy Humans Independent of Changes in Free Fatty Acids

CONTEXT: Islet β-cells express both insulin receptors and insulin signaling proteins. Recent studies suggest insulin signaling is physiologically important for glucose sensing. OBJECTIVE: Preexposure to insulin enhances glucose-stimulated insulin secretion (GSIS) in healthy humans. We evaluated whet...

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Главные авторы: Lopez, Ximena, Cypess, Aaron, Manning, Raquel, O'Shea, Sheila, Kulkarni, Rohit N., Goldfine, Allison B.
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2011
Предметы:
Endocrine Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232618/
https://ncbi.nlm.nih.gov/pubmed/21956413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2011-0627
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