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Cloning and sequence determination of a human rheumatoid factor light-chain gene.

The contribution of germ-line variable regions to autoantibody formation in humans is poorly understood. To study the gene structure of a human autoantibody, chronic lymphatic leukemia (CLL) cells from a patient with an IgM anti-IgG (rheumatoid factor, RF) paraprotein were utilized. The rearranged i...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Jirik, F R, Sorge, J, Fong, S, Heitzmann, J G, Curd, J G, Chen, P P, Goldfien, R, Carson, D A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323258/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3083417/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.7.2195
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