Cloning and sequence determination of a human rheumatoid factor light-chain gene.

The contribution of germ-line variable regions to autoantibody formation in humans is poorly understood. To study the gene structure of a human autoantibody, chronic lymphatic leukemia (CLL) cells from a patient with an IgM anti-IgG (rheumatoid factor, RF) paraprotein were utilized. The rearranged i...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Jirik, F R, Sorge, J, Fong, S, Heitzmann, J G, Curd, J G, Chen, P P, Goldfien, R, Carson, D A
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1986
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3083417/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.7.2195
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