A Phase I and Pharmacokinetic Study of Oral Lapatinib Administered Once or Twice Daily in Patients with Solid Malignancies

PURPOSE: This study determined the range of tolerable doses, clinical safety, pharmacokinetics, and preliminary evidence of clinical activity following once or twice daily administration of lapatinib in patients with solid malignancies. EXPERIMENTAL DESIGN: Cancer patients (n = 81) received oral dos...

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Bibliografiska uppgifter
Huvudupphovsmän: Burris, Howard A., Taylor, Charles W., Jones, Suzanne F., Koch, Kevin M., Versola, Melissa J., Arya, Niki, Fleming, Ronald A., Smith, Deborah A., Pandite, Lini, Spector, Neil, Wilding, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232441/
https://ncbi.nlm.nih.gov/pubmed/19825948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0369
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