A Phase I and Pharmacokinetic Study of Oral Lapatinib Administered Once or Twice Daily in Patients with Solid Malignancies

PURPOSE: This study determined the range of tolerable doses, clinical safety, pharmacokinetics, and preliminary evidence of clinical activity following once or twice daily administration of lapatinib in patients with solid malignancies. EXPERIMENTAL DESIGN: Cancer patients (n = 81) received oral dos...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Burris, Howard A., Taylor, Charles W., Jones, Suzanne F., Koch, Kevin M., Versola, Melissa J., Arya, Niki, Fleming, Ronald A., Smith, Deborah A., Pandite, Lini, Spector, Neil, Wilding, George
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232441/
https://ncbi.nlm.nih.gov/pubmed/19825948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0369
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