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Structure, Mechanism, and Inhibition of Histone Deacetylases and Related Metalloenzymes

Metal-dependent histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-L-lysine side chains in histone and non-histone proteins to yield L-lysine and acetate. This chemistry plays a critical role in the regulation of numerous biological processes. Aberrant HDAC activity is implicated in vari...

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Detalhes bibliográficos
Main Authors: Lombardi, Patrick M., Cole, Kathryn E., Dowling, Daniel P., Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232309/
https://ncbi.nlm.nih.gov/pubmed/21872466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2011.08.004
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