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Structure, Mechanism, and Inhibition of Histone Deacetylases and Related Metalloenzymes
Metal-dependent histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-L-lysine side chains in histone and non-histone proteins to yield L-lysine and acetate. This chemistry plays a critical role in the regulation of numerous biological processes. Aberrant HDAC activity is implicated in vari...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232309/ https://ncbi.nlm.nih.gov/pubmed/21872466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2011.08.004 |
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