Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways

Cryptotanshinone (CPT), isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, the underlying mechanism remains to be defined. Here we show that CPT inhibited lymphangiogenesis in an in vitro model (tube formation). This effect was partly attributed to inhibitin...

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Detalhes bibliográficos
Main Authors: Luo, Yan, Chen, Wenxing, Zhou, Hongyu, Liu, Lei, Shen, Tao, Alexander, J. Steven, Zheng, Shizhong, Lu, Yin, Huang, Shile
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232289/
https://ncbi.nlm.nih.gov/pubmed/21881029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0319
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