Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways

Cryptotanshinone (CPT), isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, the underlying mechanism remains to be defined. Here we show that CPT inhibited lymphangiogenesis in an in vitro model (tube formation). This effect was partly attributed to inhibitin...

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Bibliografiske detaljer
Main Authors: Luo, Yan, Chen, Wenxing, Zhou, Hongyu, Liu, Lei, Shen, Tao, Alexander, J. Steven, Zheng, Shizhong, Lu, Yin, Huang, Shile
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232289/
https://ncbi.nlm.nih.gov/pubmed/21881029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0319
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