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Cysteine Cathepsins in the Secretory Vesicle Produce Active Peptides: Cathepsin L Generates Peptide Neurotransmitters and Cathepsin B Produces Beta-Amyloid of Alzheimer’s Disease

Recent new findings indicate significant biological roles of cysteine cathepsin proteases in secretory vesicles for production of biologically active peptides. Notably, cathepsin L in secretory vesicles has been demonstrated as a key protease for proteolytic processing of proneuropeptides (and proho...

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Bibliografiske detaljer
Main Authors: Hook, Vivian, Funkelstein, Lydiane, Wegrzyn, Jill, Bark, Steven, Kindy, Mark, Hook, Gregory
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232284/
https://ncbi.nlm.nih.gov/pubmed/21925292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2011.08.015
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