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B ring regulation of colchicine binding kinetics and fluorescence.
Several properties of the colchicine-tubulin interaction such as association rate, reversibility, and the promotion of drug fluorescence have been related to the B ring of colchicine. The B ring itself retards the binding rate, and substitution at C-7 leads to further binding rate decreases that app...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1986
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323228/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3457374/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.7.2052 |
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