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B ring regulation of colchicine binding kinetics and fluorescence.

Several properties of the colchicine-tubulin interaction such as association rate, reversibility, and the promotion of drug fluorescence have been related to the B ring of colchicine. The B ring itself retards the binding rate, and substitution at C-7 leads to further binding rate decreases that app...

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Bibliografiske detaljer
Main Authors: Bhattacharyya, B, Howard, R, Maity, S N, Brossi, A, Sharma, P N, Wolff, J
Format: Artigo
Sprog:Inglês
Udgivet: 1986
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC323228/
https://ncbi.nlm.nih.gov/pubmed/3457374
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