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Resistance to maribavir is associated with the exclusion of pUL27 from nucleoli during human cytomegalovirus infection

Select mutations in the human cytomegalovirus (HCMV) gene UL27 confer low-grade resistance to the HCMV UL97 kinase inhibitor maribavir (MBV). It has been reported that the 608-amino acid UL27 gene product (pUL27) normally localizes to cell nuclei and nucleoli, whereas its truncation at codon 415, as...

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書誌詳細
主要な著者: Hakki, Morgan, Drummond, Coyne, Houser, Benjamin, Marousek, Gail, Chou, Sunwen
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232008/
https://ncbi.nlm.nih.gov/pubmed/21906628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2011.08.019
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