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Resistance to maribavir is associated with the exclusion of pUL27 from nucleoli during human cytomegalovirus infection
Select mutations in the human cytomegalovirus (HCMV) gene UL27 confer low-grade resistance to the HCMV UL97 kinase inhibitor maribavir (MBV). It has been reported that the 608-amino acid UL27 gene product (pUL27) normally localizes to cell nuclei and nucleoli, whereas its truncation at codon 415, as...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232008/ https://ncbi.nlm.nih.gov/pubmed/21906628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2011.08.019 |
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