ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function

BACKGROUND: The hydrogen sulfide-releasing sildenafil, ACS6, has been demonstrated to inhibit superoxide formation through donating hydrogen sulfide (H(2)S). We have found that H(2)S antagonizes homocysteine-induced oxidative stress and neurotoxicity. The aim of the present study is to explore the p...

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Hauptverfasser: Tang, Xiao-Qing, Chen, Rong-Qian, Ren, Yan-Kai, Soldato, Piero Del, Sparatore, Anna, Zhuang, Yuan-Yuan, Fang, Hen-Rong, Wang, Chun-Yan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231821/
https://ncbi.nlm.nih.gov/pubmed/22146536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-9912-1-20
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