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Phase II Trial of Dasatinib for Patients with Acquired Resistance to Treatment with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Erlotinib or Gefitinib

INTRODUCTION: Dual inhibition of SRC and EGFR -dependent pathways may overcome acquired resistance to EGFR-TKIs for patients with lung adenocarcinoma with EGFR mutations. The SRC-inhibitor dasatinib demonstrates anti-tumor activity in gefitinib-resistant cells lines and xenografts. Dasatinib is tole...

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Podrobná bibliografie
Hlavní autoři: Johnson, Melissa L., Riely, Greg J., Rizvi, Naiyer A., Azzoli, Christopher G., Kris, Mark G., Sima, Camelia S., Ginsberg, Michelle S., Pao, William, Miller, Vincent A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230574/
https://ncbi.nlm.nih.gov/pubmed/21623279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3182161508
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