Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process

BACKGROUND: The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS) process. METHODS: First, excipients for enhancing the stability and sol...

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Hlavní autoři: Kim, Min-Soo, Kim, Jeong-Soo, Park, Hee Jun, Cho, Won Kyung, Cha, Kwang-Ho, Hwang, Sung-Joo
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2011
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230567/
https://ncbi.nlm.nih.gov/pubmed/22162657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S26546
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