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Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agents.

Synthetic oligodeoxynucleotides that are covalently linked at their 3' end to an acridine derivative and are complementary to the repeated sequence UUAAAUUAAAUUAAA adjacent to the ribosome binding site of the gene 32-encoded mRNA from phage T4 have been used to regulate the synthesis of gene 32-enco...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Toulmé, J J, Krisch, H M, Loreau, N, Thuong, N T, Hélène, C
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323048/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3513172/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.5.1227
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