Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Hsp90 is an essential and highly abundant molecular chaperone protein that has been found to regulate more than 150 eukaryotic signaling proteins, including transcription factors (e.g. nuclear receptors, p53) and protein kinases (e.g. Src, Raf, Akt kinase) involved in cell cycling, tumorigenesis, ap...

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Bibliographic Details
Main Authors: Murphy, Patrick J. M., Franklin, Hannah R., Furukawa, Nathan W.
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2011
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230214/
https://ncbi.nlm.nih.gov/pubmed/21968922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/3059
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