The nature of enzyme catalysis in trypsin.

We present a combined quantum/molecular mechanical study of the trypsin-catalyzed hydrolysis of a specific tripeptide substrate, including the entire enzyme in the calculation, as well as 200 H2O molecules. The results illustrate how the enzyme and nearby H2O molecules stabilize the ionic intermedia...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Weiner, S J, Seibel, G L, Kollman, P A
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1986
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC322921/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3456162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.3.649
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