Cyclic enkephalin-deltorphin hybrids containing a carbonyl bridge: structure and opioid activity

Six hybrid N-ureidoethylamides of octapeptides in which an N-terminal cyclic structure related to enkephalin was elongated by a C-terminal fragment of deltorphin were synthesized on MBHA resin. The synthetic procedure involved deprotection of Boc groups with HCl/dioxane and cleavage of the peptide r...

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Main Authors: Ciszewska, Małgorzata, Ruszczyńska, Katarzyna, Oleszczuk, Marta, Chung, Nga N., Witkowska, Ewa, Schiller, Peter W., Wójcik, Jacek, Izdebski, Jan
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229099/
https://ncbi.nlm.nih.gov/pubmed/21584287
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