Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

RUNX1 encodes a DNA binding subunit of the core-binding transcription factors and is frequently mutated in acute leukemia, therapy-related leukemia, myelodysplastic syndrome, and chronic myelomonocytic leukemia. Mutations in RUNX1 are thought to confer upon hematopoietic stem cells (HSCs) a pre-leuk...

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Autors principals: Cai, Xiongwei, Gaudet, Justin J., Mangan, James K., Chen, Michael J., De Obaldia, Maria Elena, Oo, Zaw, Ernst, Patricia, Speck, Nancy A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228772/
https://ncbi.nlm.nih.gov/pubmed/22145044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028430
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