Runx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells

The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show, counter-intuitively, that Runx1 deficient hematopoietic stem and progenitor cells (HSPCs)...

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Publicado en:Cell Stem Cell
Main Authors: Cai, Xiongwei, Gao, Long, Teng, Li, Ge, Jingping, Oo, Zaw Min, Kumar, Ashish R., Gilliland, D. Gary, Mason, Philip J., Tan, Kai, Speck, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530029/
https://ncbi.nlm.nih.gov/pubmed/26165925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.06.002
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