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Introduction of genes into preimplantation mouse embryos by use of a defective recombinant retrovirus.
Two-cell and four-cell preimplantation mouse embryos were cocultured in vitro with fibroblasts producing the recombinant retrovirus M-MuLV-neo. No wildtype helper virus was detected in these cultures. Of the embryos that survived the in vitro cultivation and the reimplantation into foster mothers, 2...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1986
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC322859/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3455774/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.2.366 |
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