Effects of Mannose-Binding Lectin Polymorphisms on Irinotecan-Induced Febrile Neutropenia

OBJECTIVE. Mannose-binding lectin (MBL) is important in the innate immune response. MBL2 gene polymorphisms affect MBL expression, and genotypes yielding low MBL levels have been associated with an elevated risk for infections in hematological cancer patients undergoing chemotherapy. However, these...

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Hauptverfasser: van der Bol, Jessica M., de Jong, Floris A., van Schaik, Ron H., Sparreboom, Alex, van Fessem, Marianne A., van de Geijn, Fleur E., van Daele, Paul L., Verweij, Jaap, Sleijfer, Stefan, Mathijssen, Ron H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AlphaMed Press 2010
Schlagworte:
Clinical Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227891/
https://ncbi.nlm.nih.gov/pubmed/20930093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2010-0033
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