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Genetically Engineered Mouse Models of the Trinucleotide-Repeat Spinocerebellar Ataxias

The spinocerebellar ataxias (SCA) are dominantly inherited disorders that primarily affect coordination of motor function but also frequently involve other brain functions. The models described in this review address mechanisms of trinucleotide-repeat expansions, particularly those relating to polyg...

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Autores principales: Ingram, Melissa A.C., Orr, Harry T., Clark, H. Brent
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227776/
https://ncbi.nlm.nih.gov/pubmed/21810454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2011.07.016
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