A Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis

Despite compelling epidemiological evidence that folic acid supplements reduce the frequency of neural tube defects (NTDs) in newborns, common variant association studies with folate metabolism genes have failed to explain the majority of NTD risk. The contribution of rare alleles as well as genetic...

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Bibliografski detalji
Glavni autori: Marini, Nicholas J., Hoffmann, Thomas J., Lammer, Edward J., Hardin, Jill, Lazaruk, Katherine, Stein, Jason B., Gilbert, Dennis A., Wright, Crystal, Lipzen, Anna, Pennacchio, Len A., Carmichael, Suzan L., Witte, John S., Shaw, Gary M., Rine, Jasper
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227667/
https://ncbi.nlm.nih.gov/pubmed/22140583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028408
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