A Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis

Despite compelling epidemiological evidence that folic acid supplements reduce the frequency of neural tube defects (NTDs) in newborns, common variant association studies with folate metabolism genes have failed to explain the majority of NTD risk. The contribution of rare alleles as well as genetic...

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Detalhes bibliográficos
Main Authors: Marini, Nicholas J., Hoffmann, Thomas J., Lammer, Edward J., Hardin, Jill, Lazaruk, Katherine, Stein, Jason B., Gilbert, Dennis A., Wright, Crystal, Lipzen, Anna, Pennacchio, Len A., Carmichael, Suzan L., Witte, John S., Shaw, Gary M., Rine, Jasper
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227667/
https://ncbi.nlm.nih.gov/pubmed/22140583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028408
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