FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids

BACKGROUND: Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors. In several cancer cell lines, FADS2 encoded Δ6 and Δ8 des...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Park, Woo Jung, Kothapalli, Kumar S. D., Lawrence, Peter, Brenna, J. Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2011
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227664/
https://ncbi.nlm.nih.gov/pubmed/22140540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028186
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