Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus

Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of islet cells. We observed reduced β-cell mass and incre...

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Main Authors: Folli, Franco, Okada, Terumasa, Perego, Carla, Gunton, Jenny, Liew, Chong Wee, Akiyama, Masaru, D'Amico, Anna, La Rosa, Stefano, Placidi, Claudia, Lupi, Roberto, Marchetti, Piero, Sesti, Giorgio, Hellerstein, Marc, Perego, Lucia, Kulkarni, Rohit N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227614/
https://ncbi.nlm.nih.gov/pubmed/22140505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028050
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