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Direct Observation of an Enamine Intermediate in Amine Catalysis

[Image: see text] An enamine intermediate is believed to be the central feature of biological catalysts, such as aldolases and small molecule amine organocatalysts. Despite decades of investigation of naturally occurring aldolase enzymes and recent studies on designed aldolase antibodies and organoc...

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Detalhes bibliográficos
Main Authors: Zhu, Xueyong, Tanaka, Fujie, Lerner, Richard A., Barbas, Carlos F., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227542/
https://ncbi.nlm.nih.gov/pubmed/19968282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907271a
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