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Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape
To analyze B lymphocyte central tolerance in a polyclonal immune system, mice were engineered to express a superantigen reactive to IgM of allotype b (IgM(b)). IgM(b/b) mice carrying superantigen were severely B cell lymphopenic, butsmall numbers of Bcells matured. Their sera contained low levels of...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3227399/ https://ncbi.nlm.nih.gov/pubmed/22043016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102479 |
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